Elsevier pathway studio что такое
Pathway Studio
Информация о биомаркерах и сигнальных путях, вносящих вклад в развитие болезней
Без информации о процессах, происходящих в биологических системах и вызывающих болезни, невозможно определить целевые протеины для разработки новых лекарственных средств. Также, для того, чтобы определить биомаркеры, соответствующие нормальным и не нормальным состояниям, необходим доступ к значительному количеству специализированной информации, включая доступ к данным о результатах исследований. Вне зависимости от того, что является предметом изучения ученых (патологии человека или растений), возможность интерпретировать экспериментальные данные позволяет лучше понимать механизмы протекания заболеваний и ускоряет проведение исследований.
Pathway Studio предоставляет доступ к базовой биологической информации
Pathway Studio позволяет анализировать и визуализировать механизмы протекания заболеваний, экспрессию генов, а также протеомические и метаболомические данные. Pathway Studio обладает функцией поиска и является всеобъемлющим ресурсом, содержащим информацию о клеточных взаимодействиях. Кроме того, Pathway Studio позволяет импортировать экспериментальные данные исследователей и анализировать их, а также с помощью инструментов нормализации/статистических инструментов выявлять причины возникновения биологических процессов и оценивать потенциальный эффект на эти процессы. Хорошо структурированные базы данных химических реакций позволяют исследователям моделировать воздействие дифференциальной экспрессии генов и белок-белковых взаимодействий на протекание заболеваний, что оптимизирует процесс идентификации потенциальных лекарственных средств.
Влияние генетических мутаций
Последняя версия Pathway Studio предоставляет доступ к данным о вариациях в ДНК из «Cистем секвенирования нового поколения» (Next Generation Sequencing systems). Кроме того, Pathway Studio позволяет получить информацию о влиянии мутации на функции белков, о молекулярных и клеточных взаимодействиях, а также о развитии заболеваний (на основании сопоставления данных из научной литературы).
Дополните информацию, которая содержится в Pathway Studio, подробными данными о синтетических препаратах, химических веществах и зарегистрированных лекарственных средствах. ChemEffect и DiseaseFX содержат дополнительную информацию о заболеваниях и их последствиях (данные из научной литературы и ClinicalTrials.gov), что позволяет совершать плавный переход от сбора данных до формирования гипотезы и идентификации потенциальных лекарственных препаратов.
Pathway Studio Plant
Pathway Studio Plant предназначен для совершенствования фундаментальных исследований и технологий, применяемых в органическом сельском хозяйстве. Pathway Studio Plant позволяет использовать хорошо изученные модели функционирования растений, интерпретировать экспериментальные данные и формировать новые сигнальные пути для ассоциации признаков, увеличения урожайности и улучшения устойчивости к болезням.
Pathway Studio
Gain new insights with a vast knowledgebase of biological relationships
Pathway Studio at a glance
Learn how Pathway Studio can transform your research by helping you analyze your experimental data.
Biology Knowledge Graph
Discover 1.5M+ biological concepts & molecular classes connected by 3.5M+ biological relationships.
Unlock the underlying biology and drive deeper discovery
Find critically relevant and actionable information fast with best-in-class content and powerful analytical tools
Finding actionable insights relating to a particular gene, disease or biomarker requires searching the relevant literature and connecting the disparate pieces of information — often a time-consuming and tedious endeavor. Whether scientists are focused on human pathology or plant biology, an informatics solution that facilitates the interpretation of experimental data gives greater insight into the mechanisms of disease and accelerates biological research through pathway analysis. Pathway Studio is that solution.
By integrating a vast knowledgebase of biological relationships harvested from millions of published articles (full-text and abstracts) with analytical and visualization tools, Pathway Studio enables scientists to explore molecular interactions along with the cause and effect relationships associated with biological processes across multiple organisms. By harnessing the extensive content found beyond the public domain, novel discovery is both more likely and more fully supported. This integrative and comprehensive biology-based investigational framework is ideal for drug target identification, disease modeling, biomarker identification and drug repurposing.
Count on Pathway Studio to help you:
Ready to take the next step?
Pathway Studio supports however you like to work
Because every researcher and every project has unique data analysis needs, Pathway Studio is flexible in how it you can use it in your work. It supports all common laboratory data formats for proteomics, metabolomics and expression data, including NGS expression (RNA-Seq) as well as NGS variant (VCF) data. So whether you need to run a simple database query to better understand the biology of a specific gene or protein interaction, identify a potential drug target or biomarker, or build a complex disease model, you can easily access the information you need precisely when you need it. For the latest version of Pathway Studio Web, we listened carefully to customer feedback and the result is an even more powerful user interface. These recent upgrades have made Pathway Studio the easiest and fastest solution for understanding the biology of diseases.
Drive more thoughtful, meaningful decisions and research with more molecular interactions and connections
Simplified workflows, manually curated pathways, extensive content and valuable filters empower you to explore molecular interaction data and to identify more connections to your protein, disease or drug. With just a few clicks, biological context — backed by >7 million literature-based molecular interactions and >2,000 manually curated pathways — can be placed around your experimental data. Use of this exhaustive knowledgebase can accelerate innovation across academic, government and corporate institutions by enabling you to:
FAQs Pathway Studio
Pathway Studio comes in two configurations.
Pathway Studio Web can be accessed from all modern browsers. Maintained and operated by Elsevier from a centralized server, the system is always available and provides high-performance.
Pathway Studio Enterprise is available as a cloud application or as installed software on your infrastructure. It comes with Elsevier proprietary text-mining technology powerful application programming interfaces (API) for the integration of Pathway Studio into an existing research infrastructure. This allows companies to better leverage their legacy data and information.
To receive a product demonstration, please Contact Sales
Pathway Studio is offered on an annual subscription basis on a named-user basis, providing you with a username and password that will work anywhere. Alternatively, we offer corporate- or campus-wide Access licenses on a yearly subscription basis that includes user authentication via IP-recognition and has no seat-based delays or budgetary concerns about task-based searches.
Yes. Over 28 million sentences are integrated to support the facts contained in Pathway Studio so that users can check the underlying context of the facts and links to the articles and publications of origin.
The experimental data types supported by Pathway Studio analytical features include:
Note that Pathway Studio analytical features support virtually any data that can be expressed in the format of a tab-delimited file with an identifier for the gene, protein, small molecule, disease, etc. together with numerical values.
Pathway Studio Enterprise enables the simultaneous analysis of multiple data types.
Security is one of our biggest concerns. Pathway Studio Web is accessible using a HTTPS protocol. This requires port 443 to be open in a company’s firewall. Since this is a standard setting, users should have clear access to Pathway Studio Web from within their company environment.
Pathway Studio Enterprise is natively installed behind your company’s firewall, which eliminates access issues.
Yes, Pathway Studio Enterprise supports this workflow.
Please Contact Sales for more information.
Yes. Both Pathway Studio Web and Pathway Studio Enterprise support login accounts for saving imported experiments, analytical results, and pathways.
For Pathway Studio Enterprise, your company’s application administrator can create user accounts for access. Alternatively, Pathway Studio Enterprise can be integrated with your company’s authentication system such as LDAP or ActiveDirectory.
With Pathway Studio Web, users with CWA access (IP authentication) can use the system in anonymous mode without saving results, or self-register for a login account so that results can be saved.
Fact Sheets
Pathway Studio can help you analyze your experimental data to understand the biological processes critical to your work.
Download the ChemEffect fact sheet (PDF, 370.2 KB): Connect the actions of drugs and toxins on cell processes, pathways and disease.
Download the DiseaseFX fact sheet (PDF, 419.5 KB): Integrate molecular facts from clinical research to reveal a basis for the detection and mechanism of disease and therapy.
Download the web security fact sheet (PDF, 967.1 KB): Pathway Studio Web is a comprehensive collection of information with powerful security features to ensure that your research is safe and secure.
Download the Pathway Studio Plant fact sheet (PDF, 342.8 KB): Pathway Studio Plant helps plant biologists address complex crop research challenges by integrating Arabidopsis, Maize and Rice molecular relationship knowledgebase with powerful analytical and visualization tools.
Technical Specs
There are different system requirements for Pathway Studio depending on the installation platform. The minimum and recommended technical specifications can be found for each platform at the links below:
Pathway Studio web
IE 9.0 and higher, Chrome or Firefox (last 3-4 years)
Pathway Studio Desktop
Please see this document for the Pathway Studio Desktop system requirements (PDF, 18.8 KB).
For installation information about Pathway Studio Enterprise, please contact your sales representative, since these specifications are variable and dependent on the number of anticipated concurrent users.
Support Log In
Existing Customer? Log into the Pathway Studio product site and click on Support from the menu on the left.
Videos
Find Relevant Biomarkers
Learn how Pathway Studio supports the drug discovery process by helping you identify new biomarkers.
What’s in a Relationship?
Pathway Studio helps you unravel the hidden biology in data and literature. With our extensive knowledgebase of biological relationships you save time and find convincing support for your decisions.
Defined Connections
Pathway Studio Plant’s knowledgebase is based on proprietary Elsevier technology that finds and extracts facts within reference materials, and converts those facts into structured relationship evidence.
Experimental data and disease models at the heart of biological research
Disease and biomarker research relies on exhaustive literature searches to find all of the reported targets, protein-protein interactions or mutations of interest. In this case study, we look at how a customized, searchable database of all reported somatic mutations could be created to support cancer research.
The first step in identifying and validating potential drug targets, biomarkers, or understanding disease progression and response to treatments is to get a complete picture of the underlying processes driving the biology. Our solution provides easy access to published information about key biological functions, processes and interactions, helping researchers build a model of their system of interest.
Industry insights
Precision Medicine: The New R&D Paradigm
Precision medicine has significantly progressed in the last several years as it has become possible to find more tailored treatments for patients based on biomarker testing.
Read the case study
The Era of Immunotherapeutics
By boosting anti-cancer response using a patient’s own immune system, immunotherapeutics are showing incredible promise in offering more effective treatments with fewer side effects for cancer patients.
Read the white paper
Case study
Selecting the best immunotherapy targets based on melanoma disease biology
Pathway Studio helps researchers understand how secreted melanoma proteins suppress the local immune response.
More industry insights
Drug repurposing
Drug repositioning or repurposing accounts for approximately 30% of drugs and vaccines recently approved by the US Food and Drug Administration. Find out how Elsevier’s solution for disease biology can help with this process.
NGS analysis
Next Generation Sequencing technology use is expanding rapidly and accelerating the identification of rare disease-causing genes. Read more about how Elsevier’s solution for disease biology can help you make sense of NGS data.
Automated vs manual curation
The vast majority of scientific data is still published in journal articles – more than 1 million new publications each year. Discovery how Elsevier’s solution for disease biology can help you find what you need for your research.
Power of content
Not all important scientific facts are found in article abstracts. Discover the importance of reading full-text articles, and how Elsevier’s solution for disease biology can help you find what you’re missing.
Customer quotes
» Pathway Studio helped me build collaborations and identify cellular processes underlying the observed changes in my transcriptomics results.» Source: David Horvath, Principle Investigator, US Department of Agriculture
«I saved a lot of time and effort with Pathway Studio since I can just input my list of genes and and get the gene interaction between these genes, and I can always manipulate the conditions and filters to suit my study.» Source: Aravind Tallam, Graduate Student, Universitie Du Luxembourg
«Understanding better the molecular mechanisms of these diseases will bring new effective drug candidates, as well as molecular markers for early warning for incoming problems.» Source: Danail Bonchev, Professor of Mathematics, Director of Research in Bioinformatics at CSBC Computational Biology, Virginia Commonwealth Universityy
Elsevier в мире
Современная компания Elsevier («Эльзевир») – крупнейший в мире издатель научно-технической, медицинской литературы и провайдер информационных решений в области науки и образования, с годовым оборотом в 9,5 млрд. долларов. Издательский дом «Эльзевир» (Elsevier) входит в состав холдинга Reed Elsevier и представлен 7,000 сотрудниками в более 70 офисах по всему миру.
Сегодня «Эльзевир» занимает особое место в научной информационно-издательской индустрии. Имея богатый опыт издания научных журналов, книг, реферативных и иных баз данных, в издательстве постоянно ведутся разработки актуальных инновационных решений для поддержки всех аспектов научных и медицинских исследований.
Наши партнеры в мире и в России:
и многие другие ведущие зарубежные и отечественные вузы, НИИ и корпорации, а также органы государственной власти.
Портфолио издательства представлено 2,500 журналамии, 20,000 онлайн-книгами (полнотекстовая платформа ScienceDirect), специализированными реферативными базами данных: Scopus, Reaxys, Emabse, Engineering Village и др., а также инновационными системами анализа, оценки и принятия решений в научно-исследовательской деятельности SciVal.
© 2019 Elsevier, кроме контента, предоставленного третьей стороной.
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